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In this study, we reported that the RALA somatic variant led to FCD type II through activation of the mammalian target of rapamycin (mTOR) pathways. To date, the role of RALA in brain development is not yet known. RALA encodes a small GTPase of the Ras superfamily. We identified the first somatic variant of RALA in the brain tissue of a child with FCD type IIb. Purpose: In our group’s previous study, we performed deep whole-exome sequencing and targeted amplicon sequencing in the postoperative brain tissue of epilepsy patients with focal cortical dysplasia type II (FCD II).
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